Decreased Ferroportin Promotes Myeloma Cell Growth and Osteoclast Differentiation Running title: Role of Ferroportin in Suppression of Myeloma
نویسندگان
چکیده
1Department of Internal Medicine, Carver College of Medicine, the University of Iowa, Iowa City, Iowa, 52242, USA; 2Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, the University of Iowa, Iowa City, Iowa, 52242, USA; 3Department of Hematology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China. 4Department of Internal Medicine, University of Utah, Salt Lake City, Utah, 84112 Address correspondence to: Fenghuang Zhan and Guido Tricot, Department of Internal Medicine, Carver College of Medicine, the University of Iowa, Iowa City, Iowa, 52242, USA; Phone: 319.384.0066; Fax: 319.353.8377; E-mail: [email protected]; [email protected]
منابع مشابه
Decreased ferroportin promotes myeloma cell growth and osteoclast differentiation.
Iron homeostasis is disrupted in multiple myeloma, a difficult-to-cure plasma cell malignancy with lytic bone lesions. Here, we systematically analyzed iron gene expression signature and demonstrated that mRNA expression of iron exporter ferroportin (FPN1) is significantly downregulated in myeloma cells and correlates negatively with clinic outcome. Restoring expression of FPN1 reduces intracel...
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Deregulated iron metabolism underlies the pathogenesis of many human cancers. Recently, low expression of ferroportin, which is the only identified non-heme iron exporter, has been associated with significantly reduced overall survival in multiple myeloma (MM); however, the altered iron metabolism in MM biology remains unclear. In this study we demonstrated, by live cell imaging, that MM cells ...
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Citation for published version (APA): Westhrin, M., Moen, S. H., Holien, T., Mylin, A. K., Heickendorff, L., Olsen, O. E., ... Standal, T. (2015). Growth differentiation factor 15 (GDF15) promotes osteoclast differentiation and inhibits osteoblast differentiation and high serum GDF15 levels are associated with multiple myeloma bone disease. Haematologica, 100(12), E511E514. DOI: 10.3324/haemato...
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Background and Aim: Despite therapeutic improvements in recent decades, multiple myeloma (MM) still remains as one of the leading causes of death all over the world. Previous studies have indicated role of neurokinin-1 receptor (NK1R) in the pathogenesis of cancer. Therefore, we decided to evaluate cytotoxic and apoptotic effects of aprepitant (NK1R antagonist) on MM-derived KMM-1 cell line. Ma...
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Introduction: Multiple myeloma (MM) is typically presented with abundant monoclonal secretion of one type of immunoglobulin. The other classes of immunoglobulins, which are uninvolved and not secreted by malignant plasma cells, could be decreased. A number of previous studies reported the effect of suppression of uninvolved immunoglobulins on the outcome of patients with myeloma. However, its e...
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